What is BPC-157?

BPC-157 stands for Body Protection Compound and is a synthetic peptide derived from a protein found in the stomach. BPC-157 is perhaps the most popular peptide. Many people start with this one. However, if you have significant MCAS (mast cell activation syndrome), I would wait until that is calmed down more before trying. But even with MCAS, many people tolerate it well. While initially studied for its remarkable regenerative and healing properties in muscles, tendons, and the gastrointestinal tract, recent research has also unveiled its potential benefits for brain health.

Here is what we know:

• Pentadecapeptide BPC-157, composed of 15 amino acids is a partial sequence of body protection compound (BPC) and was discovered in and isolated from human gastric juice in 1993
• It's naturally produced in the GI tract and is enzymatically stable in gastric juice, meaning you can take it orally for gut issues, if needed.
• BPC-157 has no primary single effect; It has pleiotrophic effects with multiple uses
• Can be administered subcutaneously or orally (use acetate form for injection, stable form for oral)

Potential benefits of subcutaneously administered BPC-157 include:

• Very anti-inflammatory
• Increases type 1 collagen
• Immune modulating
• Neuroprotective, especially for those who have had TBI
• Modulates serotonergic and dopaminergic systems
• Repairs tissue! GI tract, tendons, ligaments, brain, bone, etc!
• Cytoprotective. Maintains GI mucosal integrity
• Potent angio-modulatory agent
• Regulates gene expression
• Increases nitric oxide (NO) and vascular endothelial growth factor (VEGF), which promotes angiogenesis and vasculogenesis. VEGF is an important signaling molecule in the growth of capillaries, which are critical to everything from wound healing to hair growth. NO and VEGF seem to suffer somewhat in people with biotoxin illness.

Potential benefits of orally administered BPC-157 include:

• Protects against and prevents gastric ulcers
• Improves GI function
• Protects and heals inflamed intestinal epithelium
• Can be used as needed during IBS flares
• Protects liver from toxic assaults and promotes healing
• Protects and helps heal gastritis
• Protects against damage from chronic NSAID use

BPC-157's BRAIN BENEFITS 

BPC-157 has demonstrated neuroprotective effects in various animal studies. It can help protect brain tissue from damage caused by traumatic brain injuries (TBI) and strokes. By reducing oxidative stress, inflammation, and apoptosis (programmed cell death) in neuronal cells, BPC-157 aids in preserving brain function and structure.

In rodent models of TBI, BPC-157 has been shown to reduce the size of brain lesions and improve functional recovery. Similar benefits have been observed in models of ischemic stroke, where BPC-157 minimized brain damage and supported neurological recovery.

BPC-157 helps modulate levels of pro-inflammatory cytokines in the brain, reducing inflammation that can contribute to neurodegenerative diseases and other brain pathologies. This anti-inflammatory action is crucial in maintaining overall brain health.

Preliminary studies suggest that BPC-157 may promote neurogenesis (the growth of new neurons) and synaptogenesis (the formation of new synapses). These processes are vital for learning, memory, and overall brain plasticity, contributing to enhanced cognitive function.

Animal studies have reported improvements in cognitive functions, such as memory and learning, following BPC-157 administration. Additionally, BPC-157 has exhibited anxiolytic (anxiety-reducing) and antidepressant effects in rodent models, indicating potential benefits for mood regulation.

BPC-157 has demonstrated the ability to accelerate muscle healing, which can be particularly beneficial for those who have suffered muscle tears, strains, or other injuries. Studies have shown that BPC-157 promotes the repair of damaged muscle tissue, reduces inflammation, and enhances overall muscle recovery.

Tendons and ligaments, which connect muscles to bones and stabilize joints, are notoriously slow to heal due to their poor blood supply. BPC-157 has been shown to significantly enhance the healing process of tendons and ligaments by promoting collagen production, reducing inflammation, and improving blood flow to the injured area.

BPC-157 has also been studied for its potential to enhance bone healing. Research indicates that BPC-157 can promote the repair of bone fractures by stimulating the production of bone-forming cells and improving the overall healing environment. This makes it a promising candidate for treating fractures and bone-related injuries.

Chronic inflammation is a common factor in many musculoskeletal conditions, including arthritis, tendinitis, and bursitis. BPC-157 has potent anti-inflammatory properties that help reduce inflammation in the affected tissues, thereby alleviating pain and promoting healing.

For individuals suffering from joint issues, such as osteoarthritis or joint injuries, BPC-157 can provide significant relief. By promoting the repair of joint cartilage and reducing inflammation, BPC-157 helps protect and restore joint health, leading to improved mobility and reduced pain.

STABLE VS. ACETATE BPC-157

“Stable form” of BPC-157 was designed for oral use. It will last for an hour in stomach acids. Acetate form is dead in under a minute if given orally. Acetate is used for injection.

Oral form of BPC-157 will only offer gastrointestinal benefits. Injectable form will offer more systemic healing benefits. This is the only peptide that I recommend as an oral supplement. All others should be subcutaneous injection or nasally (depending on the peptide). However, if you have GI issues (leaky gut, ulcers, etc), then oral BPC-157 may help. If wanting more systemic healing benefits, then you want BPC-157 as an injection.